1: Sun J, Wang H, Ng TB. Isolation of a laccase with HIV-1 reverse transcriptase inhibitory activity from fresh fruiting bodies of the Lentinus edodes (Shiitake mushroom). Indian J Biochem Biophys. 2011 Apr;48(2):88-94. PubMed PMID: 21682139. 2: Kushida T, Makino T, Tomomura M, Tomomura A, Sakagami H. Enhancement of Dectin-2 gene expression by lignin-carbohydrate complex from Lentinus edodes mycelia extract (LEM) in a mouse macrophage-like cell line. Anticancer Res. 2011 Apr;31(4):1241-8. PubMed PMID: 21508371. 3: Kawano M, Thet MM, Makino T, Kushida T, Sakagami H. DNA microarray analysis of signaling pathway in macrophages stimulated by lignin-carbohydrate complex from lentinus edodes mycelia (LEM) extract. Anticancer Res. 2010 Jul;30(7):2567-76. PubMed PMID: 20682984. 4: Kawano M, Sakagami H, Satoh K, Shioda S, Kanamoto T, Terakubu S, Nakashima H, Makino T. Lignin-like activity of Lentinus edodes mycelia extract (LEM). In Vivo. 2010 Jul-Aug;24(4):543-51. PubMed PMID: 20668322. 5: Ngai PH, Ng TB. Lentin, a novel and potent antifungal protein from shitake mushroom with inhibitory effects on activity of human immunodeficiency virus-1 reverse transcriptase and proliferation of leukemia cells. Life Sci. 2003 Nov 14;73(26):3363-74. PubMed PMID: 14572878. 6: Gordon M, Bihari B, Goosby E, Gorter R, Greco M, Guralnik M, Mimura T, Rudinicki V, Wong R, Kaneko Y. A placebo-controlled trial of the immune modulator, lentinan, in HIV-positive patients: a phase I/II trial. J Med. 1998;29(5-6):305-30. PubMed PMID: 10503166. 7: Suzuki H, Iiyama K, Yoshida O, Yamazaki S, Yamamoto N, Toda S. Structural characterization of the immunoactive and antiviral water-solubilized lignin in an extract of the culture medium of Lentinus edodes mycelia (LEM). Agric Biol Chem. 1990 Feb;54(2):479-87. PubMed PMID: 1368512. 8: Suzuki H, Okubo A, Yamazaki S, Suzuki K, Mitsuya H, Toda S. Inhibition of the infectivity and cytopathic effect of human immunodeficiency virus by water-soluble lignin in an extract of the culture medium of Lentinus edodes mycelia (LEM). Biochem Biophys Res Commun. 1989 Apr 14;160(1):367-73. PubMed PMID: 2469420. 9: Tochikura TS, Nakashima H, Yamamoto N. Antiviral agents with activity against human retroviruses. J Acquir Immune Defic Syndr. 1989;2(5):441-7. PubMed PMID: 2477523. 10: Tochikura TS, Nakashima H, Ohashi Y, Yamamoto N. Inhibition (in vitro) of replication and of the cytopathic effect of human immunodeficiency virus by an extract of the culture medium of Lentinus edodes mycelia. Med Microbiol Immunol. 1988;177(5):235-44. PubMed PMID: 3173237.